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To determine if verapamil and nifedipine, calcium entry blockers, alter the hypothalamic-pituitary-adrenal axis (HPA), the effect of these drugs on the stress-induced release of adrenocorticotropic hormone (ACTH), beta-endorphin (beta-END), and cortisol in plasma was studied. Twenty-six normal, healthy volunteers (18-22 yr) were studied, six men in the follicular phase of the menstrual cycle, and 20 men in the luteal phase of the menstrual cycle. In each patient, on separate occasions, blood samples were obtained prior to and for 3 h after the patient received placebo, 1 mg of oral nifedipine, and 10 mg of oral verapamil. In the group receiving oral verapamil, the oral temperature was maintained at 37 degrees C. In the group receiving oral nifedipine, the oral temperature was reduced to 30 degrees C. The administration of the placebo had no effect on the patients' endocrine parameters. Following oral verapamil ac619d1d87
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